You could go anywhere for a weekend getaway, but few destinations east of the Mississippi River beat\u00a0the Southeast and Mid-Atlantic regions. With more breweries, wineries and small towns than stars in the sky, how do you decide where to go? Answer, by seeking out a unique, a one-of-a-kind experience. Pack a bag, load up the cooler and get in the car. Here are 10 unique weekend getaways tailor-made for adventure.\r\nLeConte Lodge, Great Smoky Mountains National Park\r\nPro Tip: LeConte Lodge doesn\u2019t take walk-ins. This collection of primitive cabins sits on the summit of Mount LeConte in the heart of Great Smoky Mountains National Park, and depending on which route you take to get there you\u2019re looking at somewhere between a 5- and 14-mile hike in, so do yourself a favor, reserve your cabin well ahead of time. But the payoff from a steep day on the trail is excellent: the sun setting over the Smoky Mountains, a sky absolutely awash in stars, and all the cool, fresh mountain air you can breathe.\r\n\r\n\r\n\r\nThere are several trails to take, the most popular being Alum Cave Trail, Trillium Gap Trails, or the longer Boulevard (which connects the AT to LeConte) and Brushy Mountain Trails.\r\n\r\nYou need a reservation, and LeConte books a year in advance, but don\u2019t worry, you may be able to take advantage of a cancellation if you call 865\/429-5704.\r\nEdisto River Treehouses, South Carolina\r\nRecapture a moment of childhood bliss by spending the weekend in one of these three treehouses on South Carolina\u2019s Edisto River. Located on the coastal plain just outside of Charleston, they may be just a little out of the Blue Ridge, but you won\u2019t complain once on your 13-mile paddle along the cypress-lined river to one of these private getaways.\r\n\r\n\r\n\r\nThe treehouses\u2014which come in small, medium and large, sleeping up to 4, 6 and 8 respectively\u2014are situated in a secluded spot in the middle of a 160-acre private reserve and they come with a grill, cooking gear, a screened-in sleeping area and a canoe.\r\nPrimitive Cabins on the Appalachian Trail, Virginia and Pennsylvania\r\nThere are 40 cabins in the mountains along the Appalachian Trail between Charlottesville, Va., and Pine Grove, Pa. Thanks to the Potomac Appalachian Trail Club, they\u2019re kept in good repair and are available to the hiking public. Well, some of them are. The club keeps 25 reserved for PATC members, but 15 are ready for anyone to use. Of those 15 cabins, all but two are primitive, and if you\u2019ve got a bunch of hiker friends who are ready to hit the trail in Shenandoah National Park or in a corridor of southern Pennsylvania, they sleep between 4 and 12, but you\u2019ll need to make a reservation quick because they rent up fast.\r\nThe Hostel in the Forest, Georgia\r\nOn Georgia\u2019s lush coastal plain, a 133-acre forest of pine, cedar, palm and magnolia holds a secret: a hotel complete with nine treehouses and one geodesic dome. And you can stay there if you\u2019re a member (membership is $10 and you can sign up when you check in).\r\n\r\nThe Hostel opened in 1975 and retains some of that post-\u201860s hippy vibe\u2014it\u2019s peaceful beyond simple tranquility and many visitors come to use the place as a sort of spiritual retreat. Spiritual or not you can connect with nature here on your own time and in your own way, and as long as you\u2019re cool with everyone, everyone\u2019s cool with you.\r\n\r\nhttps:\/\/www.youtube.com\/watch?v=i_64jguBjy4\r\nDorothy\u2019s House, The Land of Oz\r\nIf you thought Dorothy Gale lived in Kansas and the Land of Oz was all in her imagination, think again, they\u2019re both in Beech Mountain, North Carolina. The Land of Oz, a Wizard of Oz-themed amusement park, now defunct, is only open a couple of days a year, but you can walk that Yellow Brick Road any time if you rent Dorothy\u2019s House. June through October, you can stay here, explore the part time park (which, frankly, can get a little creepy), go for a drive on the Blue Ridge Parkway, hike to some waterfalls and watch out for flying monkeys.\r\nHouseboating on Smith Mountain Lake, Virginia\r\nLet\u2019s stop thinking of Houseboating as a Tahoe-Havasu-Meade thing and bring it to the East Coast in force. Head to Smith Mountain Lake, rent a houseboat (or two, but you\u2019ll need a lot of friends to do it right) and party on the lake. Swimming, flip cup contests, kayaking, marathon card games, fishing and backflips off the top deck are just some of the ways to put your stamp on this manmade lake.\r\nCamping in Worley\u2019s Cave, Tennessee\r\nYou don\u2019t have to be a master caver to spend the night in a cave, you can do it in Bluff City, Tenn. Worley\u2019s Cave, in cave-rich Tennessee, is open for tours every day, but on weekends you can spend the night underground, no tent required, just a ground cloth and your sleeping bag (it stays a chilly 55\u02da in there). Sleep, explore some of the 4,000 feet of caverns and tunnels, then head topside to shower and camp in a meadow near the cave\u2019s entrance.\r\nSearch for the Brown Mountain Lights, North Carolina\r\nWant a weird weekend? Pack your tent and head to Morganton, North Carolina, then make your way to Brown Mountain where you\u2019ll camp in hopes of spotting, up close and personal, the legendary Brown Mountain Lights. These lights are a strange phenomenon that could be UFOs or ghosts or ball lightning or who knows what, but plenty of locals (and the author of this piece) have seen them on, over and all around Brown Mountain. Camp on the slopes and spend your days hiking to the top where some mysterious boreholes only add to the Brown Mountain question. If you get wigged out, or even if you don\u2019t, head into town and hit Fonta Flora Brewing for some liquid courage.\r\nWitch Hunt in Seneca Creek State Park, Maryland\r\nAs long as we\u2019re talking paranormal, spend a night or two in Seneca Creek State Park and see if you don\u2019t get goose bumps a time or two. Thanks to the cult film The Blair Witch Project, which filmed here, these woods will forever be tied to strange noises, witchy sculptures and someone in your party forgetting how to read a map. But don\u2019t sweat the spooky stuff, it was all for show (we hope) and these woods are loaded with hiking and mountain biking trails including the 16.5-mile Seneca Creek Greenway.\r\nWake Up in Germany, err, Helen, Georgia\r\nIn the Georgia Blue Ridge there\u2019s a unique little town called Helen that in 1969, for some reason or another (left-handed cigarettes?) the town transformed itself into a picturesque German village. A whole fa\u00e7ade of gingerbread trim and steep roofs and cobblestone streets all reminiscent of Bavaria was built, giving the town a new identity. Helen maintains its German look and goes so far as to serve German food\u2014Hansel and Gretel Candy Kitchen, Hofer\u2019s (for breakfast), and a Fried Cheese Caf\u00e9 (also serving schnitzel)\u2014and beer. Oh, and at Smithgall Woods State Park you\u2019ll find excellent trout fishing, some pretty hikes, and plenty of roads for cyclists to ride. It\u2019s an oddly charming way to spend a weekend in the mountains.